In The Politics of Autism, I discuss various ideas about what causes the condition. Dozens of potential causes and correlates have been the subject of scientific and medical research.
One peer-reviewed paper generating buzz in the autism research community published in December argues that a staggering number, more than half of autism cases, could be prevented with the right interventions. It proposes a “three-hit” theory suggesting that genetic susceptibility combined with environmental exposure and prolonged period of physiological stress contribute to autism.
Separately, two recent studies found that parents with the highest levels of an unusual sensitivity to everyday substances even at low levels, as measured by self-reported symptom patterns and validated questionnaires, were two times to 5.7 times more likely to report having a child with autism, prompting researchers to urge couples trying to conceive to minimize environmental exposures in their homes.\
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In 2024, [Claudia] Miller and her colleagues published an analysis showing that in a group of nearly 8,000 U.S. adults, parents with chemical intolerance scores in the top 10th percentile were 5.7 times as likely to have a child with autism when compared with those in the bottom 10th percentile.
Those findings were replicated in a study published in January 2026 in the Journal of Xenobiotics, which examined children in five countries. In Italy, India and the United States, children born to parents with the highest levels of chemical intolerance had more than a twofold increased risk of autism; in Mexico, the risk was 1.9 times higher. No association was found in the Japanese data, though researchers suggested cultural differences in diagnosis and awareness may have influenced the results.
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Helen Tager-Flusberg, director of Boston University’s Center for Autism Research Excellence and a founder of a coalition of autism scientists calling for more rigorous research, said there is little evidence that specific interventions during the preconception window could make a significant difference. She cautioned that focusing on this period is premature — and possibly harmful — given the current limits of the science. She pointed to the past, when both researchers and the public wrongly blamed so-called “refrigerator mothers” (who were cold or emotionally distant) and their parenting for autism.
“For decades now we’ve done too much as a society to make women feel the burden is on them,” she said.
She said the best advice for women considering pregnancy hasn’t changed for decades: take prenatal vitamins with folic acid, eat a healthy diet, stay fit, and avoid drugs, alcohol and smoking.