Yet Another Possible Correlation
AFP reports:
Children born to mothers with a hormonal imbalance run a much higher risk of developing autism, according to a new study released by Sweden's Karolinska Institutet on Tuesday.
The findings, published in the journal Molecular Psychiatry, link an imbalance called polycystic ovary syndrome (PCOS) to autism spectrum disorder (ASD) in children.
ASD represents a range of neurodevelopmental disorders in children.
In
The Politics of Autism, I write:
Because scientists lack a grand theory of autism causation – not to mention accurate knowledge of how autism prevalence has changed over the years – research has moved in a bewildering array of directions. Here is just a partial list of correlates, risk factors, and possible causes that have been the subject of serious peer-reviewed studies:
- Pesticides;[i]
- Air pollution and
proximity to freeways;[ii]
- Maternal thyroid issues;[iii]
- Autoimmune disorders;[iv]
- Induced labor;[v]
- Preterm birth;[vi]
- Birth by cesarean section;[vii]
- Maternal and paternal
obesity;[viii]
- Maternal and paternal age;[ix]
- Maternal post-traumatic
stress disorder;[x]
- Smoking during pregnancy;[xi]
- Antidepressant use during
pregnancy.[xii]
[i] Janie F.
Shelton, Neurodevelopmental Disorders and Prenatal Residential Proximity to Agricultural
Pesticides: The CHARGE Study ,” Environmental
Health Perspectives, June 23, 2014 (advance publication). Online: http://ehp.niehs.nih.gov/wp-content/uploads/advpub/2014/6/ehp.1307044.pdf.[ii] Andrea
L. Roberts et al., “Perinatal Air Pollutant Exposures and Autism Spectrum Disorder
in the Children of Nurses’ Health Study II Participants,” Environmental Health Perspectives 121 (August 2013): 978-984.
Online: http://ehp.niehs.nih.gov/wp-content/uploads/121/8/ehp.1206187.pdf;
Heather E. Volk et al., “Residential Proximity to Freeways and Autism in the
CHARGE Study,” Environmental Health
Perspectives 119 (June 2011): 873-877. Online: http://ehp.niehs.nih.gov/wp-content/uploads/119/6/ehp.1002835.pdf.[iii] Gustavo
C. Román, et al., “Association of Gestational Maternal Hypothyroxinemia and
Increased Autism Risk,” Annals of
Neurology 74 (November 2013): 733-742. Online: http://onlinelibrary.wiley.com/doi/10.1002/ana.23976/full.[iv] Lior
Brimberg, et al., “Brain-Reactive IgG Correlates with Autoimmunity in Mothers
of a Child With an Autism Spectrum Disorder,” Molecular Psychiatry 18 (November 2013): 1171-1177. Online: http://www.nature.com/mp/journal/v18/n11/full/mp2013101a.html.[v] Simon G.
Gregory, et al., “Association of Autism With Induced or Augmented Childbirth in
North Carolina Birth Record (1990-1998) and Education Research (1997-2007)
Databases,” JAMA Pediatrics 167
(October 2013): 959-966. Online: http://archpedi.jamanetwork.com/article.aspx?articleid=1725449.[vi] Michael
W. Kuzniewicz et al., “Prevalence and Neonatal Factors Associated with Autism
Spectrum Disorders in Preterm Infants,” Journal
of Pediatrics 164 (January 2014):
20-25. Online: http://www.jpeds.com/article/S0022-3476(13)01142-6/abstract?cc=y..[vii] Eileen
A. Curran et al., “Research Review: Birth By Caesarean Section and Development
Of Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: A
Systematic Review And Meta-Analysis,” Journal
of Child Psychology and Psychiatry (October 27, 2014). Online: http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12351/pdf.[viii] L C
Reynolds, et al., “Maternal Obesity and Increased Risk for Autism and
Developmental Delay among Very Preterm Infants,” Journal of Perinatology, May 8, 2014 (advance publication). Online:
http://www.nature.com/jp/journal/vaop/ncurrent/full/jp201480a.html; Pål Surén
et al., “Parental Obesity and Risk of Autism Spectrum Disorder,” Pediatrics 133 (May 2014): e1128-e1138.
Online: http://pediatrics.aappublications.org/content/early/2014/04/02/peds.2013-3664.full.pdf+html[ix] John
McGrath, et al., “A Comprehensive Assessment of Parental Age and Psychiatric
Disorders,” JAMA Psychiatry 71 (March
2014): 301-309. Online: http://archpsyc.jamanetwork.com/article.aspx?articleid=1814892;
Selma Idring et al., “Parental Age and the Risk of Autism Spectrum Disorders:
Findings from a Swedish Population-Based Cohort,” International Journal of Epidemiology 43 (February 2014): 107-115.
Online: http://ije.oxfordjournals.org/content/43/1/107.full.pdf+html.[x] Andrea
L. Roberts et al., “Women's Posttraumatic Stress Symptoms and Autism Spectrum
Disorder in Their Children,” Research in
Autism Spectrum Disorders 8 (June 2014): 608-616. Online: http://www.sciencedirect.com/science/article/pii/S1750946714000427.[xi] Phuong
Lien Tran, et al., “Smoking during Pregnancy and Risk of Autism Spectrum
Disorder in a Finnish National Birth Cohort,” Paediatric and Perinatal Epidemiology 27 (May 2013): 266–274.
Online: http://onlinelibrary.wiley.com/doi/10.1111/ppe.12043/full.[xii]
Rebecca A. Harrington, et al., “Prenatal SSRI Use and Offspring with Autism
Spectrum Disorder or Developmental Delay,” Pediatrics 133 (May 2014): e1241
-e1248. Online: http://pediatrics.aappublications.org/content/133/5/e1241.